Introduction: India is emerging as diabetic capital of world as 2nd most affected country in the world. Common microvascular complications are neuropathy, nephropathy and retinopathy. It is most common cause of preventable blindness all over the world. Hence has been included in VISION 2020. Global prevalence of DR was found to be 22.27%. In India the incidence and prevalence of diabetes and thereby DR is increasing exponentially in urban as well as rural population and involves population from all socioeconomic strata. The present study was undertaken to study the clinical profile of DR in known diabetics. It aimed to know the various factors affecting progression and pathogenesis of DR, to grade the DR, to know the complications and visual morbidity due to DR in our institution. Methods: The present Prospective Observational study was conducted in the department of ophthalmology in a tertiary care hospital and medical college. Conducted amongst 102 walk in and referred, known (Diagnosed) Diabetic patients coming to Ophthalmic OPD during Jan. 2020 to June 2021. Results: In present study majority 86.2% patients having DR were Type 2 diabetics. The male population was found to be 61.76% and the female constitute about 38.23%. Mean age was 58+13.76 years. Mean duration of Diabetes was 9.31+5.44, ranging from 1 to 25 years. 70.57% had poor control and 29.41% had very good control of sugars. Hypertension was found in 46 (45.09%) study participants. Among the 102 Diabetic patients, fasting lipid profile showed that 32.5% had higher cholesterol levels. 43.13% of the study population were on Oral Hypoglycemic Agents followed by 20% of them on insulin with 37.25% of the study population on both drugs. 64.8% patients (66) patients were affected with equal grades of DR bilaterally. 88% were diagnosed with NPDR whereas the remaining 12% were found to have PDR. PDR was diagnosed in 7.84% patients unilaterally and 3.9% patients bilaterally. Conclusion: Untreated diabetes can worsen the case hence to avoid further complication it is very necessary to incorporate regular eye check-up among the Diabetic cases along with proper diabetic treatment. Regular retinal check-up should be included in standard treatment protocols (STP) of diabetes. Early diagnosis and treatment can further limit the disability.