Background: Tobacco smoking has been recognized as the most important risk factor for chronic obstructive pulmonary disease (COPD) for a long time, but recent studies have shown that non-smokers also contribute to a significant proportion of COPD. The aim of the present study is to explore the different causes of non-smoker COPD patients and to assess their clinical profile. Methods: This study was an observational cross‑sectional study conducted in Department of Respiratory Medicine, Rajshree Medical Research Institute Bareilly. A total of 108 COPD patients of either gender with COPD, diagnosed by GOLD guideline were included in the study. Results: Out of the 108 cases studied, majority were females constituting 74.1% and mostly 83.3% belonged to rural areas. Most affected age group was 41-50 years (41.7%). The duration of illness was < 5 years among majority 67.6% subjects. History of exposure to ETS was present in all 108 patients, most of the patients i.e. 98.1% gave history of ETS exposure for >3 hours and 62% patients gave history of ETS exposure for > 10 years. Majority of the study population had symptoms of Cough and Sputum (100.0%) followed by Breathlessness (65.7%), Wheezing (21.3%) and swelling of lower limb (17.6%). Biomass fuel use was found among 79.6% subjects