Abstract Introduction: A portal pressure gradient of more than 5-10 mm Hg is diagnostic of portal hypertension, a characteristic of cirrhosis. Varices develop in patients with portal hypertension when the portal circulation is relieved by portosystemic collaterals. Methods: This prospective study comprised consecutive newly diagnosed liver disease patients with or without gastrointestinal bleeding from May 2021 to April 2022, at our tertiary referral facility General Medicine, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad. Before joining the trial, patients signed an informed consent. Results: There were a total of 80 participants in the study. The median age of the population is 45, and its age distribution is between 18 and 74. The ratio of male to female patients was 2.11 to 1. There were 62 male patients. The typical duration of symptoms was 90 days (range, 10-230 days). Fifty patients had obvious ascites, and another 43 showed pedal edoema. Conclusion: If proven effective, this would eliminate the need for expensive and intrusive examinations like gastrointestinal endoscopy and allow the use of beta-adrenergic antagonists as preventative treatments against primary variceal bleeding in patients with liver cirrhosis.