Recently, the prevalence of unstable variants of angina pectoris (NVS) among men at a young age has increased markedly. A significant role in the inflammation of the atherosclerotic plaque, which underlies the pathogenesis of NVS, is assigned to cytokines by the mediator. To date, the role of cytokine gene polymorphism in the development of NVS associated with inflammatory processes has been proven. Object: The aim of the work is to study the clinical and hemodynamic and genetic aspects of the development of NVS in men at a young age on the basis of clinical and hemodynamic parameters, genetic, biochemical markers and other risk factors. Materials and methods: 100 patients with NVS were examined on the basis of the Samarkand branch of the Republican Scientific Center for Emergency Medical Care (SFRNCEMP) from 2018 to 2020. The patients were divided into 2 groups. The first group consisted of 70 young men. The second group consisted of 15 elderly men. This group of patients was a comparison group. The control group consisted of 15 practically healthy volunteers Results: According to our results, it was found that young men, smokers who are overweight or obese, suffering from hypertension, having some form of dyslipidemia, as well as people with a hereditary predisposition to early development of cardiovascular pathology are primarily at increased risk of early development of NVS. Conclusions: There is a fact that NVS in young people is still quite a rare event, in recent years there has been a steady increase in the frequency of its occurrence. Young men, smokers, and people with a hereditary predisposition to the early development of CVD are primarily at increased risk of early development of NVS. A better understanding of the main causes and mechanisms of the development of NVS in men at a young age is a serious task of modern cardiology. The ability to predict the risk of developing CVD in young men on the basis of traditional RFS, half of which are modifiable, opens up new prospects in the formation of a strategic approach to the management of young people with high risk.