Abstract: Chronic periodontitis (CP), the most common periodontal disease, is an inflammatory disease leading to the destruction of connective tissue and loss of the adjacent supporting bone and is multifactorial in etiology. Periodontal therapy including either surgical and/or non-surgical methods usually results in improvements in periodontal health. In some cases, scaling and root planing (SRP) is insufficient to solve periodontal infection. SRP combined with local antibiotics has been shown to yield better results than SRP only. Recently, minocycline, a broad spectrum antibiotic is found to be effective against periodontal pathogenic micro-organisms. The aim of this systematic review is to evaluate the clinical efficacy of locally delivered minocycline in the treatment of periodontitis.an electronic search was carried out using the keywords, “minocycline”. “periodontal” and “periodontitis” via the PubMed/Medline, ISI Web of Science and Google Scholar databases for relevant articles published from 1949 to February 2019. The addressed focused question was: To review current literature, to analyse the efficacy of minocycline as a local adjunct to SRP in the treatment of periodontitis. Following the removal of duplicate results, the primary search resulted in articles and articles were excluded based on title and abstract. Hence, articles were read completely for eligibility. After exclusion of irrelevant studies,6 articles were included. All of them were RCT’s, all of them were human studies, were clinical and were microbial analysis.