ABSTRACT The clinical and biochemical parameters of patients with oral galvanosiswere studied. A comprehensive examination of patients with galvanosis, which included an assessment of dental and somatic status, as well as a study of the content of low- and mediummolecular-weight substances (LMMWSs) in plasma, erythrocytes and mixed saliva was held.Patients with galvanosis who were also likely to have diseases of the digestive system, diseases of the circulatory system, diseases of the nervous system prevail among comorbidities. Consequently, the course of the underlying disease in the examined patients is complicated by concomitant somatic pathology due to the observed polymorbidity.The absolute values of the current value recorded in the oral cavity do not correlate with the subjective and objective manifestations ofgalvanosis. A positive average correlation was found between the severity of the development of galvanosis and the level of impedance in the oral cavity(r=0.573, p<0.001).The high level of LMMWSs in the blood (22.12±0.77c.u.) and mixed saliva (29.88±0.62c.u.) in patients with galvanosis indicates endogenous intoxication resulting from the impairment of many organs and systems, which is confirmed by the history and examination data. The placement of dental material into the oral cavity increases the degree of toxic load and has a negative impact on the surrounding tissues and the body as a whole.