ABSTRACT: Clear cell lesions are heterogeneous groups of odontogenic and salivary gland having its origin derived from epithelial, mesenchymal, hematopoietic and melanocytic components. Clear cells are found in different tumors and these clear cells are usually identified by the histopathological sections .Benign and malignant clear cell tumors are rare in oral cavity (2%).Pathologically H and E staining method is a gold standard method for histological examination for various human diseases. Identifying the clear cell is one of the clue or proof of accurate diagnosis. There are also some other structures observed in histopathological sections like grooves,Islands,granules,inclusions,globules,halo or clearing which enables the pathologist to find out the proper and accurate diagnosis .Clear cell changes are seen in various benign , malignant and non neoplastic conditions . Clear cell tumors are affect other body parts also including CNS, skin, female urogenital tract ,head and neck areas rarely bone and soft tissue region. For an approach to clear cell tumors the pathologist must identify if the change is from artifactual or mimic like the clear cell tumors, or originally clear cell tumors from appropriate origin. This Article gives idea of the clear cell tumors and various differential diagnosis of the clear cell tumors that affect the oral cavity.