Occurrence of structural and the morphological characteristics of lip prints depend upon habitual activities of any individual, exposure of environmental factors, genetic defects, mainly involvement in consumption of illicit drugs/ alcohol. In most of the cases, it has been observed that some abnormalities occur due to genetic factors at the time of birth. Lip phenotyping helps us to determine morphometric features. Cleft lip/cleft palate is one among the craniofacial deformity that affects the phenotype of the lips. Chromosome 18q deletion syndrome is one of the syndromes causing cleft lip and cleft palate. Although aetiology of prints can be examined by ultrasound, amniocentesis yet the conclusion is established based on the affected chromosome with the help of genetic markers. This study is an attempt to find out the effect of chromosome 18q deletion and to determine identity of individual based on phenotyping1 . It can provide important clue about perpetrator involve in sexual assault cases/homicide cases where saliva/ sweat of an individual is recovered from the deceased body. Palatoscopy helps in determination of personality through palatal rugae with an application of investigative techniques.