This review article covers the current research areas in oral pathology and reflects the broad range that encompasses the development and application of software in digital histopathology, implementation of biomarkers in pathology, genetics and epigenetics. Molecular pathology, regenerative medicine and immuno therapy, holds the promising and optimistic future of pathology. Oral and maxillofacial pathology is standing at the forefront of the revolution and new diagnostic tools and knowledge are taking pathologists into broader roles of research and correlating diagnoses for clinicians. While we are still using the same method and material that has been using for the past 100years, it’s time to change. Digital technologies could push the field into becoming more efficient and more scalable. Utilizing igh-throughput, automated digital pathology scanners, it is possible to capture an entire glass slide, under bright field or fluorescent conditions, at a magnification comparable to a microscope. Digital slides can be shared over networks using specialized digital pathology software applications. The future of digital pathology could eventually encompass enhanced translational research, computer aided diagnosis (CAD) and personalized medicine.