Aim: This review aims to explore the use of cell block cytology in the diagnosis of oral lesions Background: Utilizing the science of cytopathology is cost effective, fast, simple and accurate. Over the years, with the improvements in technical aspects and the appearance of cell block technique in cytopathology, the gold standard of “must have tissue to make an accurate diagnosis” is rapidly changing. Review results: The review identified articles on use of cell block technique in oral lesions. The current research studies on this technique for oral lesions are very sparse. Most of the identified studies were limited to odontogenic lesions. Conclusion: Though the cell block technique is being practiced for more than a century now for non-oral lesions, its practice among head and neck lesions is not up to par. Being cost effective, fast, simple, accurate and requires only a small tissue sample, its utilizing in oral diseases needs to be explored further.