The prevalence and antibiotic susceptibility patterns of intestinal carriage. 19 E. Coli isolates were labelled as multidrug resistant (MDR) because they were resistant to more than three classes of antibiotics. These 19 isolates were further tested for ESBL and MBL drug resistant detection. 3 were ESBL producers which was confirmed by Double disc synergy test and 7 were MBL producers confirmed by MHT. This study highlights the importance of performing the drug resistant detection against E. coli which helps in the proper management in MDR cases and also helps in infection of E. Coli among the patients admitted to tertiary care hospitals. A total of 50 stool samples were collected from the patients who are admitted within 3 days of hospitalization. The collected samples were processed for microscopy and culture for isolation identification & isolates were processed for Antibiotic susceptibility test and detection of drug-resistant (ESBL & MBL). Out of 50 E. Coli high resistance was found in 50 samples for ampicillin (68%), ceftriaxone (66%), ciprofloxacin (58%), and cefepime (54%). control program to reduce inappropriate antibiotic.