ABSTARCT Usually physicians are familiar with the cutaneous signs in cardiac patients. They include Central and PeripheralCyanosis, Erythremia, and erythema, Digital clubbing. Some cardiac conditions usually have diagnostic cutaneous clues.Among the association of coronary heart disease, hyperlipidemia and xanthomas is important. Leopard syndrome is the rarest syndromes which have often have characteristic skin signs.Hence with this knowledge a physician can be able to diagnose and hence treatment for these diseases can be planned accordingly.