Abstract: Arthritis is a type of joint dysfunction that includes one or more joint inflammation like rheumatoid or psoriatic arthritis, and associated autoimmune disorders. The biggest concern about arthritis is that the discomfort is always persistent and may be confined to the injured joint due to swelling that happens throughout the joint, trauma to the joint induced by illness, regular wear and tear, muscle strains triggered by vigorous action toward hard sore joints and exhaustion, which in effect contributes to inflexibility, immobility and muscle weakening. Carbon nanotubes with unusual physicochemical properties (cell membrane penetration, large surface area and drug payload, biocompatibility, simple surface alteration, photoluminescence properties and non-immunogenicity) are employed to conquer the challenges of inflammation.