1. INTRODUCTION: Cantharidin is a toxic substance secreted by beetles (Spanish Fly) of the Meloidae family (Coleoptera order), these insects collectively called blister beetles and is a wellknown toxin and vesicant [1]. Cantharidin compound is an odorless, colorless in nature that is insoluble in water. It is highly irritating and causes acantholysis and vesicle formation when in contact with skin or mucous membranes. After ingestion, it is instantly absorbed from the GI tract and rapidly excreted by the kidneys [2]. Cantharidin, a bicyclic terpenoid, has an inhibitory effect on protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). It is collected in the haemolymph, genitalia and other tissues [3,4]. Spanish flies and other meloids have also been used medicinally as cutaneous irritants, vesicants, abortifacients and aphrodisiac[5].