ABSTRACT Bovine mastitis is a major setback in the dairy industry causing huge economic loss to the dairy farmers. This disease is mainly the inflammation of mammary gland which may be acute and chronic. Mastitis can be either clinical (showing prominent symptoms) or subclinical (no visible symptoms found). The milk yield is reduced drastically after the cow suffers from mastitis. Besides the low milk yield, reproductive performance is also affected with infertility and abortions occurring in the affected animals. Antibiotics therapy is the existing therapy so far which has many drawbacks. The antibiotic residue come through the milk and enters the human food chain, besides the antibiotic resistance developed by the microorganisms. Some alternative therapies like phage therapy, nano-particle based therapy, bio-therapeutics have come into existence which need further research. Proper management of the disease and the animals with prompt treatment can reduce the loss rendered by the dairy farmers in future.