Complications after trachea extubation are three times more common than complications occurring during tracheal intubation and induction of anaesthesia. Hypertension and tachycardia are well documented events during extubation. These hemodynamic responses reflects sympatho-adrenal reflex stimulation (epipharyngeal and laryngo pharyngeal stimulation) with concomitant increase in plasma level of catecholamines and activation of alpha and beta adrenergic receptors. A routine preanesthetic examination was conducted assessing the general condition of the patients on the evening before surgery. From all patients, informed consent was obtained. All patients were kept nil per oral for 8 h. On arrival in the operating room, i.v. line was established, and fluid dextrose with normal saline was started. Patients were connected to multichannel monitor which records HR, noninvasive blood pressure, end-tidal carbon dioxide, and oxygen saturation. Statistical evaluation between the group showed there was no significance of SBP between the group at basal, extubation upto 1 th minute post extubation (p>0.05). At 2th min (p=0.034), 3rd min (p-0.023) and 15th min (p=0.024) post extubation there was significance esmolol> labetalol at 2nd and 3 rd , labetalol >esmolol at 15th min.