Different levels of periodontal disorders erode the periodontal attachment. In addition to stopping these diseases, we must concentrate on regenerating and replacing the tissues that have been lost. On the other hand, the integration with the soft tissues is crucial to the success of dental implants, which are regarded as a blessing in the history of contemporary dentistry. Regardless of the chosen material and design, a successful outcome can only be obtained with the healing of the soft tissue layer positioned between the implant and the bone. Numerous biomaterials and biological mediators have been developed for years in an effort to restore the injured tissues completely using less invasive methods. Several of them are cited in various articles and evaluations from different sources as being summarized here.