ABSTRACT Qualitative and quantitative monitoring of infectious agents that pose a danger to the life of patients is a necessary component of the set of measures. Currently, the main methods for detecting serological markers of viral hepatitis diseases are enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR). Monitoring the viral load will not only allow you to effectively fight the infection, but can also play the role of a kind of marker of the adequacy of the therapy used, and also serve as the basis for individual correction of the patient management regimen. Chronic liver diseases associated with hepatitis B viruses represent one of the urgent problems of modern medicine. An accurate estimate of the number of people infected with hepatotropic viruses is difficult due to various circumstances. According to WHO experts , the hepatitis B virus infects at least 240-500 million inhabitants of the planet. The formation of chronic viral hepatitis itself is an unfavorable outcome of acute hepatitis caused by a pathological reaction of the immune system, it is not possible to eliminate the pathogen that caused acute viral hepatitis.