Bilayer tablet is an advanced form of tablet design and it‟s very useful in treatment of chronic diseases and their associated adverse disorders. It‟s also helpful in treatment where more than one drug is indulged eg. Diabetic, Rheumatoid arthritis. Now a day‟s many type of marketed bilayer preparation are available which shows a tremendous result to treat chronic disease. Bilayer tablets are used to control different types of successful drug release rate. In this review we discussed on the rheumatoid arthritis, possible treatment, how to bi-layer tablet helpful in RA treatment, bilayer formulation methods, etc. pharmaceutical incompatibility, sustain release, immediate release