Abstract: Recently, exclusive feature of small organic molecules i.e., organocatalysts like low cost, environment benign, nonmetallic, solubility, stability in normal conditions, easy availability has made it, a very attractive catalyst to unified diverse fields in synthetic organic chemistry. Organocatalysts specifically based on thiourea-amine based attained a great attention among research propagators. These catalysts are capable of activating an electrophile through hydrogen bond formation and at the same time, activate nucleophile by involving amine group. In spite of great advantage of this catalyst, a very little work has been done with it in multicomponent reactions (MCRs). To explore the applications of these catalysts in MCRs we focused on the utilization of these dual functionalility containing moieties in MCRs.