Holistic health is looking beyond the physical body and is addressing physical, emotional, social, spiritual and intellectual health. In autism there is social, social, emotional, and sometimes intellectual health impairment is observed in the child. It affects boys more than girls and actually exact number of children living with autism is not known. In autistic child there are 3 core symptom interactions observed; Social interaction difficulties, Communicationdifficulties and, Behavioral problems. Autism can occur as a result of genetic mutation, environmental risk factors during pregnancy, paternal age at higher site. The present study describes the case of childhood autism visited at Datta Meghe Ayurvedic Hospital. Child was diagnosed clinically and has been treated with Ayurvedic interventions, Panchakarma therapies and diet modification. Child has got relief symptomatically within one week of therapy started. Case study briefly explained Ayurvedic concepts regarding childhood autism and Ayurvedic treatment protocols in autistic disorder.