Background The COVID-19 pandemic in KSA resulted in a nationwide quarantine on March 27th, 2020. This study represents the assessment of rates of depression in the general population of KSA during the pandemic. The COVID-19 pandemic has created an unprecedented global crisis, necessitating drastic changes to living conditions, social life, personal freedom and economic activity. study has yet examined the presence of depression symptoms in the KSA population under similar conditions. Patients at risk of severe SARS-CoV-2 acute respiratory syndrome are characterised by the high prevalence of pre-existing diseases (high blood pressure and cardiovascular disease, diabetes, chronic respiratory disease, or cancer), most of them typically present in severely depression patients. Indeed, the biological role of adipose tissue in sustaining SARS-CoV-2 infection is not completely elucidated. Aim of the study: To assessment the awareness of the Impact of COVID-19 virus on the depression on Population at Saudi Arabia at Makkah in Saudi Arabia 2021 Method : Across-sectional study among Population residents in primary health care center in Makkah Al-Mukarramah was conducted using an online questionnaire designed during April 2021. The questionnaire collected socio-demographic characteristics, depression Symptoms in participants before and during the COVID-19 Pandemic (via the PHQ-9 patient depression questionnaire) our total participants were (200). Results: most of the participants (41.0%) were in the age group more than 60 years follow by the (37.0%)were in the age 30-40 years, the majority of them were female (27.0%) while male(28.0%), regarding the marital status most of participants married were(44.0%), regarding level of education the majority of participant are Primary/ Intermediate were(35.0%), regarding Chronic Medical conditions the majority of participant are Diabetes were(42.0%) while High blood pressure were(33.0%) , regarding the Working/studying from home most of participants answer No were(74.0%)while answer Yes were(15.33%).Conclusion: The research's showed increase in the prevalence of mental health problems and depression in the early stages of the pandemic, and these problems were predicted by several specific COVID related variables. Further similar surveys, particularly of those with children at home, are required as the pandemic progresses. In addition Anxiety and depression levels amongst Population at Saudi Arabia in healthcare were found to be high when assessed during the COVID-19 pandemic.