ABSTRACT: Introduction: COVID-19 pandemic has forced dentists to prepare themselves by updating their knowledge and receive training to face the present and after effects of COVID-19. The present survey was thus conducted to assess the knowledge, risk perception, attitude, and preparedness of the dentists in India about COVID-19. Materials and Methods: A cross-sectional online survey was carried out among registered dentists in south India. A self-administered, anonymous, questionnaire comprising of 25 close- ended questions was circulated to gather the relevant information. A total of 1120 dentists submitted a response, out of which 1000 complete responses were included in the statistical analysis. Pearson’s Chi-square test was used for inter-group statistical comparison. Results: 80% of the dentists had a fair knowledge about the characteristics of COVID-19. 61% and 50% of the dentists had taken infection control training and special training for COVID-19, respectively. 52% of the dentists had the perception that COVID-19 is very dangerous. Only 42% of the dentists were willing to provide emergency services to patients. Most of the dentists had an opinion that there is a need to enhance personal protective measures. Conclusion: In the present study, South Indian dentists have presented satisfactory knowledge with adequate awareness as the majority of them had a fair level of knowledge with significantly higher knowledge among female respondents and those with postgraduation studies. As we are going through an evolutionary phase where new advances are expected to evolve, dentists will definitely emerge successfully out from the crisis of the COVID-19 pandemic.