SCA is a genetic category of red diseases of the blood cells. People in their red blood cells contain an abnormal protein. Part of a group of SCA diseases is sickle cell anaemia (SCA). Sickle cell anaemia is a red blood cell condition that has not been inherited in the body with ample red cells to hold oxygen.. It is dangerous because it can cause extreme pain, anemia and other symptoms. The early diagnosis is required for sickle cell anemia. In this study, the automatic classification of SCA system is discussed. Initially, the input images are given to median filter for pre-processing. Then the Gray Level Co-occurrence Matrix (GLCM) and Haralick features are extracted. Finally, Random Forest (RF) classifier is used for Prediction. The performance of SCA system produces the classification accuracy of 95%using RF classifier