INTRODUCTION: Since heart failure is a significant cause of mortality and morbidity Understanding the clinical profile, risk factors, and outcome predictors in patients with heart failure is crucial. Considered to be the main electrolytes linked to the electrical characteristics of the cardiac membrane are serum sodium, potassium, and calcium, which determine four phases of the action potential following an incident of acute myocardial infarction, serum electrolyte abnormalities are frequent whose clinical significance in both STEMI and NSTEMI has not yet been fully recognised yet. With the above available literature there still seems to be a lacuna especially with regard to Indian population, hence this study was taken up mainly to assess, measure and determine serum electrolytes and its association in acute heart failure patients based on the outcomes. MATERIAL AND METHODS: This Cross-sectional study was conducted among patients attending Department of general medicine of Aarupadai Veedu Medical College Puducherry from December 2020 – November 2022 for 2 years . Inclusion Criteria were acute Heart Failure Patients above 18 years of both genders. Patients who are less than 18 years, who are Pregnant, diagnosed with sepsis and other malignancies were included. After obtaining approval from institutional ethical committee and informed & written consent from the patient. All patients were subjected to detailed history taking and clinical examination. The present study enrolled patients who were with acute heart failure confirmed by specific lab diagnosis and clinical examination. Laboratory tests like serum electrolytes, ECG, 2D ECHO, lipid profile, HbA1C, fasting blood glucose, post prandial blood glucose were done for all the patients