Background: Dietary supplements (DSs) are popular in many countries, and their use among individuals is increasing worldwide. Dietary supplements are considered as food products that contain dietary ingredients intended to supplement nutritional value to a diet. It encompasses specific vitamins, multivitamins, minerals, enzymes, amino acids, and herbs. As a balanced diet is essential for development and maintenance of the human body, dietary supplement usage has become commonplace to improve overall health and well-being, and to reduce the risk of certain diseases . Dietary supplements use has become very common in the KSA, and GCC countries. however, there are limited studies examining the characteristics of people who take supplements. The economic boom in Saudi Arabia indirectly, prompted the use of dietary supplements in the last two decades. must to investigate the prevalence of dietary supplement use and its association with socio demographic/lifestyle characteristics among Saudi female students .The Kingdom of Saudi Arabia is a fast growing economic country that has affected its general population in various ways including a transition in daily lifestyle patterns and dietary intake habits. Aim of the study : To assessment the Prevalence of Using Dietary Supplements among Physically Active Adults in Makkah Almukrramah / Saudi Arabia, 2021. Method: Cross-sectional study design. The current study was conducted at fitness time centers at Holy Capital of Makkah . Sample size will be total of 190 participants. Results: Overall, 190 participants. no significant difference between age and using supplements in the study while Chi- square 7.090 & p-value 0.527 less than 0.05. Most age of participants use supplements from 30- 35years were constitute 29.5 % while not use 25.0%, then the age from 25 – 30 years use supplements were constitute 21.45% but in the same age not use supplement were constitute 35.0% followed by age from 19-25years use supplement were constitute 18.5%. Conclusion: It is highly recommended to increase awareness measures from official health entities by educating the general population and physically active adults about dietary supplement use and adverse effects to ensure safe practices.