Background: The profunda femoris artery is the main artery supply of the thigh arising from the lateral side of the femoral artery about 3-4 cm distal to the inguinal ligament. The present study was conducted top assess variation of profunda femoris artery. Materials & Methods: 50 cadaveric specimens of lower limbs obtained and the PFA was identified and its site and mode of origin were recorded. The distance between the origin of PFA from the FA and the mid inguinal point (MIP) was measured. The relation of profunda femoris artery to FA at its origin was recorded. The mode of origin and pattern of origin of PFA from the femoral artery were also recorded.