Autism Spectrum Disorder (ASD) is a pervasive developmental disorder characterized by two key features: a combination of impairments in social interaction and social communication, and restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. Primary healthcare (PHC) are frequently a first point of contact for patients with ASD symptoms and play a crucial role in early diagnosis. Mention that early intervention is required to ensure that patients with ASD receive the proper education. ASD is a lifelong condition that affects patients. There are gaps in our understanding of how people with autism interact with healthcare professionals. Relevant studies have identified issues such as complexity that goes beyond the scope of the typical role, a lack of knowledge and resources, a lack of training or prior experience, communication and collaboration, the need for information and training, the need for care coordination and systemic changes, but no studies have looked at the knowledge levels of PHC patients in Saudi Arabia