ABSTRACT: Background: The present study was conducted to compare root resorption between Micro-osteoperforation (MOP) and Piezocision (PzC) assisted orthodontics. Materials & Methods: 36 patients requiring orthodontic treatment were divided into two groups of 18 each. Group I was treated using MOP in one side while the other side served as control. Group II was treated with PzC in one side with no intervention done on the other side. Radiographs were obtained before and after canine retraction to calculate amount of RR. Results: Root resorption in experiment side in group I before canine retraction found to be 27.90 mm and after canine retraction was 27.42 mm and on control side pre- operatively was 27.86 mm and post- operatively was 27.36 mm. The difference was non- significant (P> 0.05). Root resorption in experiment side in group II pre- operatively found to be 26.76 mm and post- operatively was 26.62 mm and on control side pre- operatively was 27.80 mm and post- operatively was 25.41 mm. The difference was significant (P< 0.05). Conclusion: Authors found significant differences in apical RR were observed between the PzC group and the control group after canine retraction. Significant apical RR were observed in the experimental PzC side compared to experimental MOP side postoperatively after canine retraction.