Introduction: A scoring system which can compare patient populations and severity of illness, objectively predict mortality, morbidity and can help to evaluate the treatment strategy is the dire need for evaluative research of intensive care. Thus, present study was undertaken to access the role of Mannheim Peritonitis Index (MPI) system in evaluation of morbidity and mortality among patients with hollow viscus perforation. Materials and Methods: The present prospective comparative study was carried among 50 patients in whom diagnosis was of peritonitis. Using history, clinical examination and laboratory values risk factors found in MPI were classified according to values indicated and individual variable scores were added to establish MPI score. The data was analyzed, each variable in the MPI score along with other patient variables was analyzed using chi square analysis with various outcomes that were noted in the study. P value <0.05 was taken as significant in this study.