Background: Denture stomatitis (DS) is the clinical diagnosis of the disease that occurs in adults with removable dentures. The present study was conducted to assess risk factors of denture stomatitis. Materials & Methods: 150 cases of complete denture wearer having denture stomatitis were diagnosed of DS based on DS-modified Newton’s index (NI): 0 = no inflammation; 1 = pin-point hyperemia; 2 = diffuse erythema; and 3 = papillary hyperplasia) in the complete denture wearers. Denture hygiene and year of denture wearing was also recorded. Results: Out of 150 patients, males were 90 and females were 60. Grading 0 was seen in 0%, 1 in 20%, 2 in 25% and 3 in 55%. The difference was significant (P< 0.05). Denture age was 1-5 years in 42%, 5-10 years in 23% and >10 years in 35%. Denture hygiene was good in 26%, satisfactory in 24% and poor in 50%. The difference was significant (P< 0.05).