Abstract: Background: COVID-19 is a pandemic caused by novel Corona virus; it has infected millions of people and caused mortality of more than half million people around globe. Objective: The study aimed to assess risk factors of infection with COVID-19 among health care workers (HCW) from different aspects. Methods: A cross sectional study was applied based upon a WHO assessment protocol to explore the real facts and situation leading to Health Care Workers infections. Results: The current study has shown that health care workers were often affected by the disease exploring that males and young age employees had predominantly higher percentage of infection. Regarding the occupation, it was clear that doctors were the most often symptomatic (45%) of the total studied samples; 46% contracted the infection through contact with patients at work. Finally the study illustrated that only 46% tried their best to protect themselves from infection and 4 out of 44 cases denied the existence of the pandemic. Conclusion: It was concluded that males were predominantly infected, patients with longer exposure had higher rate of infection and those properly using PPE had less chance to acquire the disease.