Online ISSN: 2515-8260

Assessment of prevalence of vitamin D deficiency among chronic liver diseases patients and its correlation with severity of liver diseases: An observational study

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SPSingh1 , NitinSoni2 , SouravBansal3 , HarjeevanSingh Kalra4

Abstract

Background: Vitamin D insufficiency and deficiency are prevalent in almost half the healthy population of developed countries. The role of vitamin D in the pathogenesis of Chronic liver diseases (CLDs) is not fully understood.Hence; the present study was conducted with the aim of assessing the prevalence of vitamin D deficiency among chronic liver diseases patients and its correlation with severity of liver diseases.Materials & methods: A total of 50 patients with presence of chronic liver diseases were included. Complete demographic and clinical details of all the patients were obtained. A Performa was made and spectrum of clinical profile of all the patients was recorded. Blood samples were obtained and serum vitamin D levels were obtained using auto-analyzer. Grading of the patients was done using Child-Pugh Score grading. All the results were recorded and analyzed by SPSS software.Results: Vitamin D deficiency was seen in 84 percent of the patients. Vitamin D levels among patients with Grade A, Grade B and Grade C of ChildPugh score grade was found to be 32.36 ng/mL, 22.12 ng/mL and 16.48 ng/mL respectively. Significant results were obtained while correlating Vitamin D levels with Child-Pugh grade.Conclusion: Patients with chronic liver diseases have significantly altered Vitamin D metabolism. Hence; Vitamin D deficiency directly correlates with severity of disease.

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