Background. Anemia is defined as a hemoglobin concentration of less than 11 g/dL in children. Anemia was found to be prevalent in 56.6 percent of the population. The significant prevalence of anemia shows that it might be a contributing factor in hospitalization, especially given the short length of stay and the likelihood that the patient was anemic at the time of enrollment. According to the World Health Organization, Iron Deficiency Anemia is a global dietary problem. At least one third of the population has been anemic at some point in their lives. Since children are more susceptible to anemia, this is particularly crucial. It could be attributed to the patients' poor overall dietary condition, including their microelement intake. Increased penetration of supplements and fortifying programs, as well as other measures aimed at preventing and controlling anemia, are strongly advised. Anemia is a global problem that can affect the neurodevelopment and behaviour of infants. A study shows that 52% of infants attending well-baby clinics in Saudi Arabia had iron deficiency anaemia. Aim of the study: To assessment of Prevalence and Determinants of Anaemia among Infants attending well-baby clinic at Primary Health Care Centres, Makkah Al-Mokarramah, 2021.Methods. A cross-sectional study was conducted at Makkah Al-Mokarramah primary healthcare centers (Al-Ka’akyah) in January, 2021. Infants who visited the well-baby clinic for vaccination/routine follow-up were selected through convenience sampling technique. A questionnaire filled out by the researcher through an interview with the mother of infants was utilized for data collection. Results. Ninety-nine ( 1 year old) infants have included in the study wherein males represent 54.5% of them . All were of Saudi- nationality and majority of them (94.9%) live with both parents. Slightly more than one-quarter of them (27.3%) were first birth order. More than three-fourth (83.8%) had weight of >3 kg. For their respective mothers, all (99%) except one were Saudis, having the age to range between 23 and 45 years with a mean of 28.8 years (SD=3.7). Conclusion. This study provides evidence of a gap in assessment to anaemia is a common problem among infants aged one year in Makkah AlMokarramah as it affects almost one-quarter of them also iron deficiency anemia(IDA) is still the most prevalent type of anemia; however, it was found in only 6.3% participants.