Background: Patient satisfaction with nursing care quality in tertiary centers significantly influences healthcare outcomes. This study aimed to comprehensively assess patient satisfaction across various dimensions of nursing care. Methods: A cross-sectional study was conducted with 400 patients admitted to tertiary centers. A structured questionnaire, encompassing communication, responsiveness, professionalism, and overall experience, was employed. Data collection occurred through face-to-face interviews and electronic surveys. Results: High satisfaction levels were reported in communication (87%), professionalism (92%), and overall experience (85%). However, responsiveness scores (79%) indicated a marginally lower satisfaction level. Correlation analysis revealed strong positive associations between communication, responsiveness, professionalism, overall experience, and overall satisfaction (p < 0.001). Comparative analysis across departments showed varying satisfaction levels, with Neurology demonstrating the highest (9.1 out of 10). Discussion: The findings underscore the significance of effective communication, professionalism, and overall experience in shaping patient satisfaction. Areas for improvement, particularly in responsiveness, warrant focused interventions to enhance nursing care delivery. Comparative analyses highlight department-specific nuances requiring tailored approaches. Conclusion: Understanding patient perspectives and addressing identified dimensions collectively is essential to elevate nursing care standards within tertiary centers. Implementing targeted interventions based on these findings holds promise in improving patient-centered care delivery and overall healthcare quality.