Aim: Purpose of the present research was to assess onset as well as progression of chemoradiotherapy (CRT) induced oral complications in head and neck cancer patients. Methodology: A prospective study conducted among 40 patients with HNC undergoing CRT. Oral complications onset and grades of severity at different time points on a weekly basis for six weeks were assessed. Weekly pairwise comparisons of oral complications was done using the Friedman one‑way repeated measure analysis of variance (ANOVA). The Chi‑squared test was done in oral candidiasis to determine the significance between groups (P < 0.05)