Background: To assess increased first trimester serum uric acid as a predictor of gestational diabetes mellitus. Materials and Methods: Seventy- six antenatal women in first trimester were selected for the study. Approval from ethical review committee was obtained. Patients’ consent was obtained before starting the study. 5 ml venous blood sample was taken from antenatal women of less than 12 weeks of gestation. Venous sample was measured after fasting, one hour and two hours and assessed for GDM using ADA criteria. Results: Age group 20-25 years had 11, 26- 30 years had 34, 31-35 years had 20, 36-40 years had 6 and 41-45 years had 5 patients. The difference was significant (P< 0.05). Parity found to be primi in 46 and multi in 30. GTT was normal in 68 and positive in 8. Serum uric acid was elevated in 27 and normal in 49 cases. The difference was significant (P< 0.05). Out of 27 patients with elevated uric acid, 26 had normal GTT and out of 49 normal uric acid patients, 42 had normal GTT. Conclusion: There was increase in the risk of development of GDM with increased levels of serum uric acid in the first trimester.