Online ISSN: 2515-8260

Assessment of glycated haemoglobin level in non-diabetic overt hypothyroid patient

Main Article Content

Vidya Sagar Ram1 , Amit Varshney2

Abstract

ABSTRACT: Background: Dysfunction and anatomic abnormalities of the thyroid are among the most common diseases of the endocrine glands. Almost one-third of the world’s population lives in areas of iodine deficiency and present study determines the association ofglycated haemoglobin level in non-diabetic overt hypothyroid patient. Materials & Methods:130 subjects of both genders were divided into 2 groups. Group I comprised of 70 patients with overt hypothyroidism and group II were 60 subjects (control group) with no thyroid dysfunction. HbA1c was measured by immunoturbidimetry method by clinical chemistry analyzer and serum TSH and FT4 were measured by radio immune assay. Results: Common clinical features were hoarseness of voice in 65%, fatigue in 53%, weight gain in 70%, depression in 42%, puffy face in 35%, non- pitting edema in 39%, cold intolerance in 31% and constipation in 22%. The mean TSH level in group I was 18.2 mIU/l and in group II was 3.4 mIU/l, FT4 level was 5.0 pmol/l in group I and 12.4 pmol/l in group II, HbA1c level was 5.9% in group I and 5.2% in group II and FBS level was 5.2 mmol/l in group I and 4.7 mmol/l in group II. The difference was significant (P< 0.05). There was correlation between TSH and HbA1c levels (r- 0.412, p< 0.05). Conclusion: Hypothyroid patients had high level of glycatedhemoglobin level as compared to control subjects.

Article Details