Background: There are various prostate pathologies. Among all, Benign Prostatic Hyperplasia (BPH) is a common health issue among ageing men globally. The present study was conducted to assess correlation of various prostate pathologies with serum prostate specific antigen. Materials & Methods: 58 male patients with various prostate pathologies presenting with LUTS underwent DRE and were worked up with USG KUBP, Serum PSA and biopsy. A trans-abdominal ultrasound examination was done to assess the size of the prostate gland. Patients with suspicious DRE finding or increased Serum PSA levels (defined as more than 4 ng/ml) underwent prostate biopsy Results: Age group 50-60 years had PSA level 3.5 ng/ml, 61-70 years had 15.4 ng/ml and 71-80 years had 11.9 ng/ml. The difference was significant (P< 0.05). IPSS was mild in 29, moderate in 23 and severe in 6 patients. PSA (ng/ml) level in mild patients was 4.7, in moderate was 6.2 and in severe was 13.7. PSA (ng/ml) level in prostate grade I patients was 4.16, in grade II was 12.3 and in grade III was 31.5 and in grade IV was 42.6. The difference was significant (P< 0.05).