Background: The incidence of prostatic lesions increases with increasing age. The present study was conducted to assess correlation between increasing PSA levels and neoplastic lesions of prostate. Materials & Methods: 80 patients of prostate pathologies were included. In all patients, prostate-specific antigen (PSA) values were recordedusing chemiluminescent assay. Transurethral resection of prostate (TURP) biopsies was fixed in 10% formalin, processed and stained with Haematoxylin and Eosin for histopathological examination. Results: BPH was seen in 48, HGPIN in 6, LGPIN in 4, prostatitis in 10 and adenocarcinoma in 12 cases. Age group 40-50 years had 12, 2, 2, 2 and 4 cases respectively. Age group 50-60 years had 18, 2, 1, 3 and 2, 60-70 years had 10,1,1,3,3 and >70 years had 8, 1,0,2 and 3 patients respectively. The difference was significant (P< 0.05).PSA 0-7 ng/ml had 32 cases of BPH, 9 cases of prostatitis, 7 cases of HGPIN, 5 cases of LGPIN. 7-14 ng/ml had 6, 2, 3, 1, 14-21 ng/ml had 4, 21-28 ng/ml had 2 cases of BPH and 5 cases of adenocarcinoma and >35 ng/ml had 12 cases of adenocarcinoma respectively. The difference was significant (P< 0.05).