Background:Hyperthyroidism is the cause of thyrotoxicosis, a pathological condition caused by increased secretion of thyroid hormones in the blood, and it is important to note that hyperthyroidism and thyrotoxicosis Aim:The current study aims was to evaluate the serum levels of adiponectin, lipid profile, malondialdehyde and glutathione in women with thyrotoxicosis and hyperthyroidism Materials and methods:In this study conducted in Kirkuk, blood samples were collected from 110 women aged 25 to 45 years, divided into five groups representing different thyroid conditions and a control group. The participants were categorized as untreated hyperthyroidism, hyperthyroidism undergoing treatment, untreated thyrotoxic women, thyrotoxic women undergoing treatment, and healthy women without thyroid disorder. Blood samples were collected using a 5 ml syringe via vein puncture, and after clotting, the sera were separated through centrifugation. The collected samples were analyzed for adiponectin levels, lipid profile parameters (total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol), as well as oxidative stress markers including malondialdehyde (MDA) and glutathione (GSH).