Weaning is a complex process of a gradual introduction of complementary foods to the infant’s diet. It is recommended that solid food is introduced between 6 and 12 months of age. Weaning is difficult and potentially dangerous time for infants’ growth and mother’s education is an established determinant of its success. Little is known about weaning attitudes or practice among mothers in the Saudi Arabia. The weaning is a process by which the baby gets used to eating adult's food slowly and relies less and less on breastfeeding (BF). It should start between four and six months of age. It is an important public health strategy for improving the child health.e origins of the word ‘weaning’ are traceable to the AngloSaxon expression “wenian” meaning “to become accustomed to something different” . Weaning from breastfeeding is considered a natural and inevitable stage in the development of human child. Weaning is a complex process involving adjustment to a range of nutritional, immunological, biochemical, and psychological changes. Weaning may mean the complete cessation of breastfeeding (‘abrupt’or final wean) , ami of this study to assessment the level of knowledge about weaning and its practice among mothers, therefore the awareness of mothers about weaning will be increased, and inappropriate weaning practices and its complications will be decreased., the beginning of a gradual process of the introduction of complementary foods to the infant’s diet .e very first introduction of foods other than breast milk is, by definition,the true beginning of weaning . Breastmilk is the ideal food for infants . It is safe and clean and contains antibodies which help protect against many common childhood illnesses. Breastmilk provides all the energy and nutrients. Ami of the study: To assess the level of knowledge about weaning and its practice and associated factors among mothers attending PHCCs in Makkah Al-Mokarramah, 2021.Methods: This was an analytical cross-sectional study conducted during 2021 among mothers in Makkah Al-Mokarramah. Stratified and Systematic random samplingtechnique was applied and an Arabic self-administered questionnaire used for data collection.Result:shown, the results of the Weaning Knowledge a significant higher relation were (50.0%) while p=0.001 and X2 63.42. regarding the Weaning Practicing Weaning no significant higher relation were (43.0%) while p=0.0018 and X2 12.66Conclusion:Various weaning methods were used, and mothers identified numerous factors as impeding their efforts to follow proper breastfeeding practices. The findings highlight the need to develop personal skills among mothers to prepare nutritionally balanced diets.