Background: One of the most common complications of diabetes mellitus is diabetic foot ulcer. Autologous platelet-rich plasma (PRP) has garnered the greatest interest among the wound-healing methods that have advanced greatly in recent years. Locally active growth factors are released by platelets, which is known to initiate the healing process after a wound. Autologous PRP studies have not shown strong data to support its utility in wound healing, hence more meticulously planned blinded trials are required. Methodology: Patients visiting the department of Dermatology in a private medical institute from 2020 to 2021 who had been diagnosed with a chronic, non-healing diabetic foot ulcer and who met the inclusion criteria were recruited and randomly divided into two groups. One group (PRP Group) received care for glycemic control, wound cleaning, wound debridement, infection therapy, application of PRP, and appropriate dressings. For the second group (Control Group), glycemic control therapy, wound cleaning, wound debridement, infection management, and appropriate dressings were administered. Results: Out of the 42 respondents , majority were between agr group 51-60, nearly 71.4% were male.Study reespondets were from various occupations. The mean HbA1c was 6.86% with standard deviation 0.68 in PRP group. In control group the mean HbA1c was 6.69% with 0.85 as standard deviation Conclusion: The PRP group experienced better and quicker healing of the ulcer than the control group, demonstrating the higher efficacy of platelet rich plasma therapy. Throughout the trial, no unfavourable impacts were noticed. To sum up, platelet rich plasma therapy is an easy, affordable, and reliable therapeutic method that can be used to safely treat persistent diabetic foot ulcers.