ABSTRACT Aquasomes are novel spherical nanovesicular drug carrier that ranges from 60 to 300 nanometer in size. They are self-organizing architectures through the action of different bonds e.g. ionic, non-covalent and van der waals forces. Aquasomes are constructed from three main components i.e. core substance, coating material and the loaded drug. The core mainly acts as a support for the polyhydroxy oligomers to enhance the structural stability of the formulations whereas the coating material is responsible for protecting the loaded pharmaceutical bioactive substances from dehydration. They are chiefly studied for delivering acid labile molecules like proteins and peptides. Nevertheless, they have potential in achieving higher solubility of poorly aqueous soluble drugs by imparting hydrophilicity to the poorly aqueous soluble drugs. Aquasomes also proved to have double targeting since sustained as well as targeted delivery approach can be achieved. Some of the mainly used sugars as coating material, different preparation techniques, applications and evaluation parameters are thoroughly discussed in the article.