Abstract: Experience in treating diaphysis fractures of the lower third of the thigh was analyzed in 82 patients. We have determined the indications for the use of methods of osteosynthesis of these fractures and the terms of implementation. The indications for surgery were closed and open fractures of the diaphysis fractures of the lower third of the femur. In closed cases, external osteosynthesis was performed using external extra-bone fixators, which were both the final and intermediate stages of treatment. For open fractures, operations were performed on a delayed basis using the Ilizarov apparatus in 5 (6%) cases. In 38 patients, osteosynthesis with fixation developed by us with a plate was performed, BIOS was performed in 8 patients and in 12 patients with AO plates, in 19 patients, various external fixators. The long-term results of treatment were studied in -66 (80.4%) patients: excellent in 27 (41%), good in 21 (32%), satisfactory in 17 (25.5%), 1 (1.5%) unsatisfactory.