Apigenin, is a nutraceutical agent which belongs to the flavanoid group. It has antioxidant, anti-inflammatory, antiviral properties. Owing to its properties its healing potential has been researched in medical field for diabetes, cancer, Alzheimer's diseases, amnesia, depression, insomnia, knee osteoarthritis, anxiety disorders, multiple sclerosis. The role of apigenin in dentistry has been studied regarding its effect on S.mutans (Streptococcus mutans), reparative dentin formation, remineralization of dentin, use of apigenin along with fluoride, dental adhesives and composite, proliferation of osteoblasts, regeneration of pulpodentinal complex, effect on periodontal ligament, and anticancer properties.