Abstract: Hepatotoxicity is an emerging medical problem. It has multiple etiological factors but most common reason is chronic treatment with certain drugs during the cure of numerous life threatening diseases. Antitubercular drugs are the leading cause of injury or damage to liver. So this is a challenging task to prevent the drug induced hepatotoxicity during tuberculosis treatment. Generally it results into interruption of treatment and cause re-emergence of this disease. This review article highlights the different mechanisms of anti-tubercular drug induced hepatotoxicity, its incidence and clinical management.