Background: Medicinal plants are the “backbone” of traditional medicine, which means more than 3.3 billion people in the less developed countries utilize medicinal plants on a regular basis. Medicines derived from plants are widely famous due to their safety, easy availability and low cost. Herbal medicines may include whole parts of plant or mostly prepared from leaves, roots, bark, seed and flowers of plants. Present study established the antioxidant potential of Alangium salvifolium by studying the efficacy in preventing the in-vitro free radical using DPPH and reducing power assay. Methods: In vitro Antioxidant Activity 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging activity and reducing power assay Result: Free radicals are highly reactive compounds that can produce oxidative stress on the body contributing to diseases such as atherosclerosis or cancer. The radical- scavenging activity of the pet ether extract, ethyl acetate extract and methanolic extracts of Alangium salvifolium was estimated by comparing the percentage inhibition of formation of DPPH radicals with that of ascorbic acid. The DPPH radical scavenging activity of pet ether extracts increased with increasing the concentration. The total antioxidant activity of Alangium salvifolium in flower was assessed based on scavenging activity of DPPH free radicals. Conclusion: Therefore, present study concludes that Alangium salvifolium is an excellent medicinal plant which holds numerous bioactive phytochemicals and it can be used in prevention of cancer.