Abstract Chiang Da (Gymnemainodorum) is a woody, climbing traditional medicinal herb which has many therapeutic applications. It has an important role in plasma glucose levels. Chiang Da has clinical evidence to treat diabetes and tradition antidiabetic formulation showed their hypoglycemic potential by any one or all the mechanism of increase secretion of insulin; promotes regeneration of islet cells and increase utilization of glucose. As the synthetic agents act by only one pathway but the herbal remedies have to show the various pathways due to their phytochemicals to treat diseases. The details of these effects for Chiang Da and their supporting animal and clinical studies have been discussed in this review.