Some bacteria become resistant to many different antibioticsare called as multidrugresistant. Multidrug-resistant bacteria isdifficult to treat andspread the antibiotic resistance gene. Methicillin, as the first beta-lactamase resistant penicillin, was used to treat Staphylococcusaureus infection in 1961. The first methicillin-resistant S. aureus (MRSA) was identified in the United Kingdom in the same year. It appeared in the United States in 1981 among intravenous drug users. Methicillin-resistant Staphylococcus aureus (MRSA) is an important agent of hospital-acquired infection. Nasal swabs samples were collected from Nalagarh civil hospital patients and all swabs samples were cultured on Mannitol salt agar. Age, sex, name, ward/infection, date of admission to hospital were recorded. Gram’s staining, Catalase test, DNase test, coagulase tests were done.Out of 20 nasal samples, 12Staphylococcus aureus were recovered. HIMEDIAHiCromeMeReSa Agar Base (M1674) + MeReSa Selective Supplement (FD229) were used in order to detect MRSA, only 03 Staphylococcus aureus were recovered out of total 12 isolates. Antibiotic susceptibility was tested by using the disk diffusion technique on Mueller-Hinton agar.